Pleiotropic anti-myeloma activity of ITF2357: inhibition of IL-6 receptor signalling and repression of miR-19a and miR-19b
نویسندگان
چکیده
| 1 | haematologica | 2009; 94(12)
منابع مشابه
Pleiotropic anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19b.
BACKGROUND The histone deacetylase inhibitor ITF2357 has potent cytotoxic activity in multiple myeloma in vitro and has entered clinical trials for this disease. DESIGN AND METHODS In order to gain an overall view of the activity of ITF2357 and identify specific pathways that may be modulated by the drug, we performed gene expression profiling of the KMS18 multiple myeloma cell line treated w...
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